I played an interesting game on the Star Realm app today:

Now to any player of the game will know that this is an unusual game. A lot of cards are in play. Recently, to make this game more interesting, I was wondering what was the higest amount of damage I could inflict in a single turn. This was the first time I broke the 500 damage mark.
There are a few particular cards needed to actually achieve a high damage cound. Since I’m bored, I’ll go into more details. But first, some additional information:
- I have the core set, gambits, 1 year promo cards, and bases (the last three are in-app purchases)
- I delayed killing the opponent for as long as I wanted
- Opponent is AI on medium difficulty (as shown in the screenshot)
So here it is:
The most overpowered card in the deck, in my humble opinion, is the Blob World Base.

Allowing you to draw one card per Blob card in play is absolutely insane. So how many Blob cards are in deck with the expansions listed above? Here is the list
Units:
- 3 Blob Fighters
- 2 Blob Pod
- 3 Trade Pod
- 2 Ram
- 2 Blob Destroyer
- 1 Battle Blob
- 1 Blob Carrier
- 1 Mothership
- 2 Battle Screecher
- 1 Obliterator
Bases:
- 3 Blob Wheel
- 2 Trade Wheel
- 1 The Hive
- 1 Blob World
- 1 Breeding Site
18 units and 8 Bases. So potentially 26 additional cards. Actually it’s possible to bump that number to 28 using two of these cards:

So drawing 20+ cards in a turn won’t get you 500+ damage. There are a few other cards you’ll need to accomplish this:

Both these cards allow you to return the Battle World from play back into your hand. Allowing you to put it back into play and using it’s ability again. There are 2 Battle Barges in the deck and 1 Mega Mech. That said, I don’t know if it’s possible to draw all 26 Blob cards and both Merc Cruisers before using the Blob World. If possible, then in the best case scenario you could draw 112 cards in a single turn - plus the 5 you start with. If you have the Fleet HQ that’s 117 points of damage right there.
Oh wait, I forgot about the Stealth Needle!

Copy the Mega Merc and pick up another 20+ cards.
Now if you’re opponent isn’t absolutely conspiring with you to lose, it’ll likely take some of the Blob cards. I never got all the Blob units in a single game - and without having a human player willing to just pick up Explorers, you will likely never get that lucky (plus get both Merc Cruisers, both Battle Barges, the Mega Mech, and the Stealth Needle - and all the other high damaging cards you’ll need). You just need a lot of luck to get the right cards at the right time.